Clinical manifestations and pregnancy outcomes of COVID-19 in indonesian referral hospital in central pandemic area
- Author:
Muhammad Ilham Aldika AKBAR
1
;
Khanisyah Erza GUMILAR
;
Rino ANDRIYA
;
Manggala Pasca WARDHANA
;
Pungky MULAWARDHANA
;
Jimmy Yanuar ANAS
;
Ernawati
;
Muhammad Ardian Cahya LAKSANA
;
Gustaaf DEKKER
Author Information
- Publication Type:Original Article
- From:Obstetrics & Gynecology Science 2022;65(1):29-36
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:Data on the clinical manifestations and pregnancy outcomes of pregnant women with COVID-19 are limited, particularly in developing countries. The aim of this study was to analyze the clinical manifestations and pregnancy outcomes in COVID-19 maternal cases in a large referral hospital in Indonesia.
Methods:This study used a prospective cohort design and included all pregnant women with suspected COVID-19. Subjects were divided into COVID-19 and non-COVID-19 groups based on the results of real-time polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2. Clinical characteristics, laboratory results, and pregnancy outcomes were compared between the two groups.
Results:Of the 141 suspected maternal cases, 62 cases were COVID-19-confirmed (43.9%), while 79 suspected cases were negative (56.1%). The clinical manifestations and laboratory findings between the two groups were not significantly different (P>0.05). However, the maternal mortality directly caused by COVID-19 was significantly higher than that in the non-COVID-19 group (8.3% vs. 1.3%; P=0.044; odd ratio, 6.91; 95% confidence interval, 0.79-60.81).
Conclusion:The clinical manifestations and laboratory results of suspected pregnant women with positive and negative RT-PCR COVID-19 results were similar. However, within the Indonesian setting, COVID-19 significantly increases the risk of maternal death through both direct and indirect factors.
