A New Dimeric Lignan from the Stems of Willughbeia edulis
- Author:
Hai Xuan NGUYEN
1
;
Truong Nhat VAN DO
;
Tho Huu LE
;
Phu Hoang DANG
;
Mai Thanh THI NGUYEN
;
Nhan Trung NGUYEN
Author Information
- Publication Type:Origianl Article
- From:Natural Product Sciences 2022;28(2):53-57
- CountryRepublic of Korea
- Language:English
- Abstract: As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acidcatalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show α-glucosidase inhibitory activity with an IC 50 value > 250 μM.
