Recurrent Hematuria due to Renal Hypouricemia.
- Author:
Kyu Young KIM
1
;
Il Soo HA
;
Hae Il CHEONG
;
Yong CHOI
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Renal hypouricemia;
Presecretory defect;
Pyrazinamide suppression test;
Probenecid suppression test
- MeSH:
Adolescent;
Diagnosis;
Hematuria*;
Humans;
Korea;
Male;
Probenecid;
Pyrazinamide;
Uric Acid
- From:Journal of the Korean Pediatric Society
1995;38(1):129-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A marked low concentration of serum uric acid(0.7-1.2mg/dl) was detected in a 14-year-old boy with recurrent episodes of gross hematuria. The hypouricemia accompanied with a markedly increased urinary clearance of uric acid (32.6-56.0ml/min), which was only minimally changed after both the administration of pyrazinamide, and inhibitor of the renal tubular secretion of uric acid, and the administration of probenecid, and inhibitor of the renal tubular reabsorption of uric acid. Other renal tubular functions were normal. There were no other family members with hypouricemia. Thies is the first case report of isolated renal hypouricemia due to presecretory reabsorption defect of uric acid in the renal proximal tubule in Korea. And renal hypouricemia should be included in the diagnosis of hematuria.
