Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.
- Author:
Ji Seok KIM
1
;
Misoo CHOI
;
Chan Hee NAM
;
Jee Young KIM
;
Byung Cheol PARK
;
Myung Hwa KIM
;
Seung Phil HONG
Author Information
- Publication Type:Case Report
- Keywords: Glomerulonephritis; Immunoglobulin A; Linear IgA bullous dermatosis; Drug eruptions
- MeSH: Carbamazepine; Ceftriaxone; Celiac Disease; Drug Eruptions; Edema; Exanthema; Extremities; Female; Glomerulonephritis; Glomerulonephritis, IGA*; Humans; Immunoglobulin A*; Kidney; Linear IgA Bullous Dermatosis; Liver Abscess; Metronidazole; Middle Aged; Purpura, Schoenlein-Henoch; Skin; Skin Diseases*; Vancomycin
- From:Annals of Dermatology 2015;27(3):315-318
- CountryRepublic of Korea
- Language:English
- Abstract: Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schonlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, and other causes. So far, only a few cases of IgA bullous dermatosis coexisting with IgA nephropathy have been reported. A 64-year-old female receiving intravenous ceftriaxone and metronidazole for liver abscess had purpuric macules and papules on her extremities. One week later, she had generalized edema and skin rash with bullae and was diagnosed with concurrent linear IgA dermatosis and IgA nephropathy. After steroid treatment, the skin lesion subsided within two weeks, and kidney function slowly returned to normal. As both diseases occurred after a common possible cause, we predict their pathogeneses are associated.
