Anaphylaxis to Polyethylene Glycol (Colyte®) in a Patient with Diverticulitis.
10.3346/jkms.2016.31.10.1662
- Author:
So Hee LEE
1
;
Sun Hyuk HWANG
;
Jin Soo PARK
;
Hae Sim PARK
;
Yoo Seob SHIN
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. drsys93@naver.com
- Publication Type:Case Report
- Keywords:
Polyethylene Glycols (PEG);
Anaphylaxis;
Diverticulitis
- MeSH:
Absorption;
Adult;
Anaphylaxis*;
Basophils;
Causality;
Diverticulitis*;
Dyspnea;
Eating;
Emergency Service, Hospital;
Gastrointestinal Tract;
Histamine;
Humans;
Intradermal Tests;
Membranes;
Polyethylene Glycols*;
Polyethylene*;
Polymers;
Risk Factors;
Tryptases;
Unconsciousness
- From:Journal of Korean Medical Science
2016;31(10):1662-1663
- CountryRepublic of Korea
- Language:English
-
Abstract:
Polyethylene glycols (PEGs) are believed to be chemically inert agents, but larger PEG polymers could have immunogenicity. A 39-year-old man was referred to emergency room for loss of consciousness and dyspnea after taking of PEG-3350 (Colyte®). In laboratory findings, the initial serum tryptase level was increased to 91.9 mg/L (normal range: 0.00-11.40 mg/L) without any other laboratory abnormalities. The intradermal test with 10 mg/mL Colyte® showed a 5 × 5 mm wheal, but basophil activation and histamine releasability tests were negative. PEG-3350 is widely used as an osmotic laxative due to its lack of absorption from the gastrointestinal tract. However, the loss of mucosal integrity at gastrointestinal membrane such as diverticulitis may be a predisposing factor for anaphylaxis to Colyte®. We report a case of anaphylaxis induced by the ingestion of PEG-3350 in a patient with diverticulitis which might be a risk factor of anaphylaxis.
