Prevalence of Y chromosome microdeletions among infertile Mongolian men
- Author:
Erdenesuvd DAMDINSUREN
1
;
Purevjargal NAIDANSUREN
;
Mendsaikhan GOCHOO
;
Bum-Chae CHOI
;
Min-Youp CHOI
;
Bolorchimeg BALDANDORJ
Author Information
- Publication Type:Original Article
- From:Clinical and Experimental Reproductive Medicine 2022;49(2):101-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men.
Methods:A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined.
Results:Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%.
Conclusion:The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.
