Effect of Ginkgo Biloba Extract on Intestinal Function after Spinal Cord Injury in Rats
10.3969/j.issn.1006-9771.2015.04.007
- VernacularTitle:银杏叶提取物对脊髓损伤后大鼠肠道功能的影响
- Author:
Xinrui LI
;
Lan LUO
;
Zheng YANG
;
Qiang WANG
;
Qiang SONG
;
Yong CHEN
;
Qian HUANG
;
Huan NIE
;
Jianmin CHEN
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba extract, spinal cord injury, malondialdehyde, superoxide dismutase, gastrointestinal dysfunction
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;21(4):397-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Ginkgo biloba extract (EGb) on intestinal function after spinal cord injury (SCI) in rats. Methods 36 Sprague-Dawley rats were randomly divided into group A (n=12), group B (n=12) and group C (n=12). SCI model was established with Allen's mode (10 g×25 mm) at T10. 30 minutes later, group A was intraperitoneally injected with methylprednisolone 30 mg/kg every 24 hours; group B was injected with Shuxuening injection (EGb) 1.75 mg/kg every 24 hours; group C were injected with equal volume of saline. The slow wave of intestinal smooth muscle was measured, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum were determined 1 day, 3 days and 7 days after modeling, while intestinal tissue was tested with HE staining. Results The amplitude and frequency of the myoelectric slow wave increased in the groups A and B 3 and 7 days after modeling compared with those in the group C (P<0.05); meanwhile, the activity of SOD increased and content of MDA decreased in the groups A and B (P<0.05). The HE scores decreased in the groups A and B compared with those in the group C (P<0.05), which presented that the inflammatory exudation was mild, the hemorrhagic spot was few and the area was limited. The intestinal villous of the group C was blunt with large infiltration of inflammatory cells and inflammatory exudate on the mucosal surface. Conclusion EGb can improve the recovery of intestinal function in rats spinal cord injury through antioxidant.
