Mycophenolate Mofetil in Combination with Tacrolimus in Adult Living Donor Liver Transplant Recipients.
- Author:
Jai Young CHO
1
;
Kyung Suk SUH
;
Choon Hyuck KWON
;
Nam Joon YI
;
Kuhn Uk LEE
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. kssuh@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Mycophenolate mofetil;
Tacrolimus;
Liver transplantation;
Outcomes;
Tolerability
- MeSH:
Adult*;
Allografts;
Creatinine;
Humans;
Immunosuppressive Agents;
Liver Transplantation;
Liver*;
Living Donors*;
Survival Rate;
Tacrolimus*;
Transplantation*
- From:The Journal of the Korean Society for Transplantation
2006;20(1):84-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This is a trial attempting to show that the addition of mycophenolate mofetil (MMF) can reduce toxicity without impacting efficacy in patients undergoing adult living donor liver transplantation (LDLT) who experience adverse events on tacrolimus (Tac). METHODS: Between February 1999 and December 2002, 47 cases of adult LDLT were administered Tac as a first-line immunosuppressive agents. Patients were categorized to a Tac Group (Tac+steroid; n=24) or a Tac/MMF Group (Tac+steroid+MMF; n=23). RESULTS: The actuarial 2-year patient survival rate was similar in the two groups (91.3% vs. 87.0%, P=0.591), and the 2-year rejection-free survival rate was also comparable (95.2% vs. 90.0%, P=0.672). In 14 patients with nephrotoxicity, mean creatinine levels decreased significantly from 1.80+/-0.24 mg/dL to 1.31+/-0.30 (P=0.001) within 3 months of adding of MMF. Of two patients with neurotoxicity, the clinical symptoms of one patient improved after adding MMF. In 7 patients with a lower therapeutic level, the mean Tac doses could be reduced from 6.4+/-4.0 mg at study entry to 2.4+/-1.4 mg 12 months after adding MMF. CONCLUSION: The addition of MMF to Tac is a potent immunosuppressive agent to reduce the Tac-induced toxicity, and which does not increase the risk of allograft rejection in LDLT.
