The role of STAT3 in inflammatory bowel disease and colitis-associated cancer and research progress of the related drugs
10.16438/j.0513-4870.2022-0533
- VernacularTitle:STAT3信号在炎症性肠病及结肠炎相关结直肠癌发生发展中的作用和相关药物研究进展
- Author:
Xiao-fan CHENG
;
Hu-tai-long ZHU
;
Ling LIU
;
Jing LUO
;
Zhi-jie SUN
;
De-li DONG
- Publication Type:Research Article
- Keywords:
signal transducer and activator of transcription 3;
ulcerative colitis;
Crohn′s disease;
inflammatory bowel disease;
colitis-associated cancer;
intestinal barrier;
immunity;
inflammation
- From:
Acta Pharmaceutica Sinica
2022;57(8):2253-2261
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription (STAT) 3 is a critical transcription factor for cell proliferation and survival. It is activated within cells by many cytokines to mediate immune and inflammatory responses to injury. Inflammatory bowel disease (IBD), represented by Crohn′s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the intestinal tract. STAT3 has been shown to be abnormally activated in IBD colon tissues by many pro-inflammatory cytokines, leading to disruption of the intestinal mucosal barrier and excessive innate immune and Th17 responses. The persistent chronic inflammation eventually leads to intestinal fibrosis and stenosis. In addition to immune responses, STAT3 is also involved in intestinal fibrosis in IBD by promoting the transcription of fibrosis-related genes. Colitis-associated cancer (CAC) is a particularly aggressive subtype of colorectal cancer and is associated with chronic inflammation-induced IBD. STAT3 has also been associated with CAC initiation and development. STAT3 is overactivated in tumors, which leads to suppression of the anti-tumor activity of immune cells and promotion of cancer cell proliferation, tumor angiogenesis, invasion, and migration. In the present article, we summarize the role of STAT3 in IBD and CAC and the research progress of the related drugs developed for UC and CAC treatment.
