Study on the chemical constituents of the fruits of Psidium guajava
10.16438/j.0513-4870.2022-0285
- VernacularTitle:番石榴果实化学成分研究
- Author:
Yue YU
;
Xing-yan SUN
;
Kai-ling XU
;
Chuang-jun LI
;
Jin-hua WANG
;
Dong-ming ZHANG
- Publication Type:Research Article
- Keywords:
italic>Psidium guajava;
fruit;
chemical constituent;
meroterpenoid;
anti-tumor
- From:
Acta Pharmaceutica Sinica
2022;57(8):2416-2422
- CountryChina
- Language:Chinese
-
Abstract:
italic>Psidium guajava Linn. is an evergreen shrub or small tree of Psidium Linnaeus in the Myrtaceae family. One new glycoside (1) together with 3 known meroterpenoids (2-4) and 9 known glycosides (5-13) were isolated from the fruits of Psidium guajava Linn.. The structure of the new compound was elucidated by the spectroscopic data analysis of HR-ESIMS, 1D- and 2D-NMR, and it was named psiguaoside A (1). The known compounds were identified as guajadial (2), 4,5-diepipsidial A (3), psidial A (4), chrysin-8-C-β-D-glucoside (5), 2,6-dihydroxy-3,5-dimethyl-4-O-β-D-glucopyranosyl-benzophenone (6), quercetin-3-O-β-D-glucopyranoside (7), quercetin-3-O-xyloside (8), guaijaverin (9), avicularin (10), guavinoside E (11), guavinoside B (12), guajaphenone A (13). In the bioactivity assay, compound 3 exhibited significant inhibitory activitiy of U87 with IC50 values of 8.379 μmol·L-1.
