Effects of Learning Environment on Learning and Memory and Microvessel Density in Hippocampus of Rats after Cerebral Infarction

VernacularTitle:探索学习环境对脑梗死大鼠学习记忆能力及缺血侧海马区微血管密度的影响
Author: Xiangyang MA ; Liping ZHANG ; Jing DONG ; Dongdong HUANG ; Dongmei LIU ; Ruzhi SUN
Publication Type:Journal Article
Keywords: cerebral infarction, learning environment, learning and memory, microvessel density, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2015;(1):42-44
CountryChina
Language:Chinese
Abstract: Objective To study the effects of learning environment on learning memory and microvessel density in hippocampus of rats after cerebral infarction. Methods 80 Sprague-Dawley rats were coagulated right middle cerebral arteries electrically, and randomly divided into learning envionment (LE) and standard environment (SE) groups. They were tested with Morris Water Maze 7 d and 28 d after operation. The microvessel density in hippocampus was measured with CD34 immunohistochemstry 1, 3, 7, 14 and 28 days after operation. Results The achievement of Morris Water Maze was significantly better in the LE group than in the SE group (P<0.001), while the microvessel density in the hippocampus was more since 7 days after operation (P<0.05). Conclusion The learning environment can promote the angiogenesis and improve the learning and memory function recovery.