Epitope specificity of Porphyromonas gingivalis heat shock protein for T-cell and/or B-cell in human atherosclerosis.
10.5051/jkape.2003.33.2.179
- Author:
Jung Gyu BAK
1
;
Sung Jo KIM
;
Jeom Il CHOI
Author Information
1. Department of Periodontology, College of Dentistry, Pusan National University, Korea.
- Publication Type:Original Article
- Keywords:
Porphyromonas gingivalis heat shock protein;
Epitope;
Atherosclerosisz
- MeSH:
Atherosclerosis*;
B-Lymphocytes*;
Cardiovascular Diseases;
Cell Line;
Cytokines;
Epitopes;
Epitopes, B-Lymphocyte;
Heat-Shock Proteins*;
Hot Temperature*;
Humans*;
Immunoglobulin G;
Peptides;
Plaque, Atherosclerotic;
Porphyromonas gingivalis*;
Porphyromonas*;
Risk Factors;
Sensitivity and Specificity*;
Shock;
T-Lymphocytes*
- From:The Journal of the Korean Academy of Periodontology
2003;33(2):179-191
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, the present study was performed to evaluate the T cell immune responses specific to Porphylomonas gingivalis(P. gingivalis) heat shock protein(hsp) 60 and T-cell and B-cell epitope specificities for P. gingivalis hsp60 in atherosclerosis. Anti-P. gingivalis IgG antibody titers were elevated in all patients. We could establish P. gingivalis hsp-specific T cell lines from the atheroma lesions, a mixture of CD4+ and CD8+ cells producing the cytokines characteristic of both Th1 and Th2 subsets. of 108 overlapping synthetic peptides spanning whole P. gingivalis hsp60 molecule, ten peptides with common epitopes specificities for both T-cell and B-cell were identified. it was concluded that P. gingivalis hsp60 might be involved in the immunoregulatory process of atherosclerotic diseases with epitope specificities.
