A new flavone glycoside from Eriocaulon buergerianum
10.16438/j.0513-4870.2022-0133
- VernacularTitle:谷精草中1个新的黄酮苷类化合物
- Author:
Yong ZHANG
1
,
2
,
3
;
Akber Aisa HAJI
1
,
3
;
Wei-liang ZHU
1
,
2
,
3
Author Information
1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
2. CAS Key Laboratory of Receptor Research, Stake Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3. University of Chinese Academy of Sciences, Beijing 100049, China
- Publication Type:Research Article
- Keywords:
italic>Eriocaulon Linn.;
italic>Eriocaulon buergerianum Koern.;
flavone glycoside;
chemical constituent;
anti-inflammatory
- From:
Acta Pharmaceutica Sinica
2022;57(7):2139-2145
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated from the water extract of Eriocaulon buergerianum by HP20, ODS, Sephadex LH-20 and MCI Gel CHP-20 column chromatographic methods. Their structures were identified by spectroscopic and chemical approaches as 6-methoxyquercetin-3-O-(2′′′-vanilloyl)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (1), syringaresinol-4′-O-β-D-glucopyranoside (2), rutin (3), 1-O-feruloylglycerol (4), 1,2-benzenediol (5), vomifoliol (6), β-D-(6-O-trans-feruloyl) fructofuranosyl-α-D-O-glucopyranosied (7), dihydroferulic acid (8), guanosine (9) and quercetin-3-O-β-gentiobioside (10). The compound 1 is a new compound, the compounds 2 and 4-10 were obtained from Eriocaulon genus for the first time, and the compound 3 was isolated from this plant for the first time. Molecular docking study showed that 1 is a potential inhibitor of TNF-α. The compound 1 was evaluated for their anti-inflammatory activities in vitro, and 1 showed significant inhibitory activity against TNF-α production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells at the concentrations of 1, 10 and 100 μmol·L-1.
