Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49
10.16438/j.0513-4870.2021-1868
- VernacularTitle:海绵共附生真菌Alternaria sp. F49抗氧化次级代谢产物研究
- Author:
Yu-shi CHEN
;
Jia-rong LENG
;
Shu-ting LIN
;
Shao-yun WANG
;
Yong-qi TIAN
- Publication Type:Research Article
- Keywords:
sponge-derived fungus;
italic>Alternaria sp. F49;
secondary metabolite;
DPPH free radical scavenging activity;
ABTS free radical scavenging activity
- From:
Acta Pharmaceutica Sinica
2022;57(7):2120-2125
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents from the the deep-sea fungus Alternaria sp. F49. Seven compounds were isolated from the EtOAc extract by using silica gel, Sephadex LH-20, ODS and HPLC methods. Based on the spectroscopic analysis, their structures were identified as (8R)-5-O-methyl-orcinotriol (1), orcinotriol (2), α-acetylorcinol (3), 3'-hydroxyalternariol 5-O-methyl ether (4), altenusiol (5), altenusin (6), and 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (7). (8R)-5-O-Methyl-orcinotriol (1) is a new phenolic compound which has never been reported in the literature. Compounds 4-7 showed strong DPPH free radical scavenging activity; whereas compounds 1-7 showed strong ABTS free radical scavenging activity.
