Phage display technology and its application in antivirals discovery
10.16438/j.0513-4870.2021-1860
- VernacularTitle:噬菌体展示技术及其在抗病毒药物发现中的应用
- Author:
Shi-qi XU
;
Zi-han HE
;
Bing-zhuo TAO
;
Xin QIN
- Publication Type:Research Article
- Keywords:
phage display technology;
antiviral drug;
viral infectious disease;
peptide;
protein
- From:
Acta Pharmaceutica Sinica
2022;57(7):1937-1945
- CountryChina
- Language:Chinese
-
Abstract:
The COVID-19 outbreak has drawn attention to viral infectious diseases once again, and the development of antiviral drugs for both known and potentially emerging viruses is of great significance. In recent years, peptides and protein drugs are becoming a hot spot in the field of antiviral drug research and development. Phage display technology, as a powerful tool for screening peptides and protein drugs, has been increasingly concerned in the academic and industrial fields. The present review introduced the basic principle of phage display technology, summarized phage display libraries often used in antiviral drug discovery and their applications, discussed the challenges and future direction of antiviral drug research and development based on phage display technology.
