Secondary metabolites from the dandelion-derived endophytic fungus Epicoccum sorghinum 1-2
10.16438/j.0513-4870.2021-1804
- VernacularTitle:一株蒲公英内生真菌Epicoccum sorghinum 1-2次级代谢产物研究
- Author:
Bao-cong HAO
1
,
2
,
3
;
Yao-yao ZHENG
1
,
2
,
3
,
4
;
Xu CHEN
1
,
2
,
3
;
Qiu-xia CHEN
1
,
2
,
3
;
Ruo-nan JI
1
,
2
,
3
;
Min CHEN
1
,
2
,
3
Author Information
1. Marine Science &
2. Technology Institute, College of Environmental Science &
3. Engineering, Yangzhou University, Yangzhou 225127, China
4. Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
- Publication Type:Research Article
- Keywords:
andelion-derived endophytic fungus;
italic>Epicoccum sorghinum;
secondary metabolite;
epoxydon;
antibacterial activity
- From:
Acta Pharmaceutica Sinica
2022;57(7):2115-2119
- CountryChina
- Language:Chinese
-
Abstract:
The secondary metabolites from the dandelion-derived Epicoccum sorghinum 1-2 were isolated by silica gel and Sephadex gel column chromatography, and semi-preparative high performance liquid chromatography (HPLC). Their structures were identified by comprehensive NMR and MS methods. Their antibacterial activities were determined by filter paper method. Finally, seven compounds were isolated and identified from the fermentation product of E. sorghinum 1-2, including (4R*,5R*,6S*)-4,5-dihydroxy-6-(6'-methylsalicyloxy)-2-methoxymethyl-2-cyclohexen-l-one (1), (4R*,5R*,6S*)-4,5-dihydroxy-6-(6′-methylsalicyloxy)-2-methyl-2-cyclohexen-1-one (2), (4R,5R,6S)-4,5-dihydroxy-6-(6'-methylsalicyloxy)-2-hydroxymethyl-2-cyclohexen-1-one (3), (-)-gabosine E (4), theobroxide (5), 3-chlorogentisyl alcohol (6), and 3-hydroxybenzyl alcohol (7), of which 1-5 are epoxydons, and 6 and 7 are phenolics. Compounds 1 and 2 are new structures reported for the first time. Compound 6 showed significant antibacterial activity against Staphylococcus aureus.
