Drug-induced blood cell dyscrasia associated with phenobarbital administration in a dog.
10.14405/kjvr.2015.55.4.263
- Author:
Han Byeol JUNG
1
;
Min Hee KANG
;
Hee Myung PARK
Author Information
1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea. parkhee@konkuk.ac.kr
- Publication Type:Case Report
- Keywords:
leukopenia;
neutropenia;
phenobarbital;
thrombocytopenia
- MeSH:
Adolescent;
Anemia;
Animals;
Blood Cells*;
Diagnosis;
Dogs*;
Dyspnea;
Female;
Fever;
Humans;
Korea;
Lethargy;
Leukopenia;
Neutropenia;
Phenobarbital*;
Seizures;
Thrombocytopenia
- From:Korean Journal of Veterinary Research
2015;55(4):263-266
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 13-year-old, spayed, female Chihuahua dog was referred for evaluation of fever, lethargy, and dyspnea. Hematologic evaluation revealed severe neutropenia, thrombocytopenia, and mild anemia. The dog had been undergoing phenobarbital therapy for the past 7 weeks because of generalized seizures due to meningoencephalomyelitis of unknown etiology. After ruling out other possible causes of cytopenias, a tentative diagnosis was made of drug-induced blood cell dyscrasia. The neutropenia and thrombocytopenia resolved after discontinuation of phenobarbital (8 days and 15 days after discontinuation, respectively). This is the first case report in Korea to demonstrate blood dyscrasia associated with idiosyncratic adverse effects of phenobarbital.
