Alopecia areata in a spayed pug: clinical and immunohistochemical findings.
10.14405/kjvr.2015.55.4.267
- Author:
Seul Gy PARK
1
;
Chang Min LEE
;
Jae Ik HAN
;
Seung Gon KIM
;
Ha Jung KIM
;
Hee Myung PARK
Author Information
1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea. parkhee@konkuk.ac.kr
- Publication Type:Case Report
- Keywords:
alopecia areata;
autoimmune disease;
T lymphocyte
- MeSH:
Alopecia Areata*;
Alopecia*;
Antigens, CD4;
Autoimmune Diseases;
Female;
Hair;
Hair Follicle;
Humans;
Immunohistochemistry;
Lymphocytes
- From:Korean Journal of Veterinary Research
2015;55(4):267-269
- CountryRepublic of Korea
- Language:English
-
Abstract:
A two-year-old spayed female pug presented with symmetrical hyperpigmented alopecic lesions on her axillary and inguinal regions. There were no remarkable findings in dermatologic examinations and hormonal assays. Histological examination of biopsied tissues revealed prominent lymphocytic perifolliculitis along with shrunk hair follicles. Immunohistochemistry for CD3, CD79a, CD4, and CD8 showed a positive stain for CD4 antigen around hair bulbs, suggesting CD4 positive T lymphocyte infiltration. This case suggests the possibility that CD4 T lymphocyte-mediated inflammatory reaction could be a main mechanism in canine alopecia areata. Additional studies are warranted to investigate the immunological mechanism in canine species.
