Recent progress of novel circular RNA regulating chemotherapy resistance in glioma
- VernacularTitle:新型环状RNA调控胶质瘤化疗耐药的最新进展
- Author:
Zhaomu ZENG
1
,
2
;
Chao LIU
2
;
Lina LIU
2
;
Xichao WEN
1
;
Qiuguo HE
2
;
Yansong GUO
2
;
Kebin ZHENG
1
Author Information
1. Dept. of Neurosurgery，the Affiliated Hospital of Hebei University，Hebei Baoding 071000，China
2. College of Clinical Medicine，Hebei University，Hebei Ba oding 071000，China
- Publication Type:Journal Article
- Keywords:
circular RNA;
glioma;
chemotherapy resistance;
mechanism
- From:
China Pharmacy
2022;33(15):1916-1920
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is a malignant tumor with extremely high rates of recurrence. Clinically ，with the prolongation of the use of chemotherapy drugs ，the drug resistance of glioma cells to chemotherapy drugs is also increasing ，which eventually leads to poor prognosis and shortens overall survival time of patients. It is well known that the development of drug resistance involves multiple mechanisms，including drug transport metabolism ，apoptosis，DNA damage repair ，autophagy，variation of cancer stem cells and epithelial mesenchymal transition. Abnormal expression of circular RNA （circRNA），a novel RNA molecule with unique stability and tissue specificity ，has been shown by more and more evidence to play a crucial regulatory role in the development of drug resistance in glioma. This paper systematically reviews the mechanism of multiple drug resistance in glioma ，and focuses on the role and molecular mechanism of circRNA regulating temozolomide-resistance in glioma. At the same time ，the potential function of circRNA as a new therapeutic target is prospected ，in order to provide an objective theoretical basis for the development of new therapeutic methods.
