High-throughput screening of drug residues in aquatic products by liquid chromatography-electrostatic field track well high resolution mass spectrometry
10.19428/j.cnki.sjpm.2022.22043
- VernacularTitle:高通量液相色谱-静电场轨道阱高分辨质谱法筛查水产品药物残留
- Author:
Qiuchi CHI
1
;
Ying PAN
1
;
You WU
1
;
Jing CHEN
1
;
Yumo LI
1
;
Luwen ZHANG
1
;
Yan CHEN
1
Author Information
1. Shanghai Institute for Food and Drug Control， Shanghai 201203， China
- Publication Type:Journal Article
- Keywords:
high resolution mass spectrometry;
electrostatic field orbital trap mass spectrometry;
high-throughput;
aquatic product;
drug residue
- From:
Shanghai Journal of Preventive Medicine
2022;34(6):526-532
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveIn order to ensure the food safety of cultured aquatic products in China， strengthen the supervision and improve detection efficiency， a high-throughput screening method for drug residues in aquatic products by mass spectrometry is to be developed. MethodsLiquid chromatography-electrostatic field track well high resolution mass spectrometry and C18 column were used to separate and collect the information of ion fragments and retention time of 195 veterinary drug standards in positive ion mode， and drug residues in aquatic products were extracted by organic solvents. ResultsThe mass spectrum database and detection methods of 195 veterinary drug standards were established， and a pre-treatment method was developed for extracting veterinary drug residues from aquatic products by acetonitrile and ethyl acetate. The detection method was sensitive， accurate， simple and rapid， and the adding standard recovery of more than 80% compounds reached 70%‒110%. ConclusionThe establishment of this method can quickly and massively screen drug residues in aquatic products， provide technical support for food safety risk monitoring and supervision， cope with the increasing demand for aquatic products and aquaculture volume year by year， and provide a theoretical basis for the subsequent development of mass spectrometry high-throughput detection methods.
