Research progress of the mechanism for PD-1 molecule regulating pulmonary fibrosis and its research prospects in silicosis
10.3969/j.issn.1006-2483.2022.04.028
- VernacularTitle:PD-1分子调控肺纤维化的机制进展及其在矽肺病研究中的展望
- Author:
Zesheng CHEN
1
,
2
;
Yiming WU
1
,
2
;
Ting ZHOU
3
;
Zhe PENG
2
;
Tingming SHI
2
;
Xiuqing CUI
2
Author Information
1. School of Public Health , Wuhan University , Wuhan , Hubei 430071 , China
2. Hubei Provincial Center for Disease Control and Prevention , Wuhan , Hubei 430079 , China
3. Hubei Province Key Laboratory of Occupational Hazard Identification and Control , Wuhan University of Science and Technology , Wuhan , Hubei 430065 , China
- Publication Type:Journal Article
- Keywords:
Programmed death factor-1;
Pulmonary fibrosis;
Silicosis;
PI3K/AKT;
JAK/STAT3;
p38MAPK;
ERK
- From:
Journal of Public Health and Preventive Medicine
2022;33(4):118-123
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death factor-1 (PD-1) is a promising target molecule for clinical tumor immunotherapy in recent years. Recent studies suggest that PD-1 and related signaling pathways (PI3K/AKT, JAK/STAT3, p38MAPK, ERK, etc.) played a key regulatory role in the process of pulmonary fibrosis. Silicosis is a systemic disease caused by inhalation of free silicon dioxide dust, which is mainly characterized by extensive pulmonary nodular fibrosis and seriously endangers the health of patients. Dissecting the role of PD-1 in the pathogenesis of silicosis may be of great significance in the mechanism research and clinical diagnosis and treatment of silicosis. This paper reviews the regulation of PD-1 molecule on related signaling pathways and its role in pulmonary fibrosis, and looks forward to the potential application of these mechanistic studies in silicosis research.
