Analysis of CD4+ T cell count of different genotypes of HIV infected people in Xi'an in 2017 -2021
10.3969/j.issn.1006-2483.2022.04.016
- VernacularTitle:2017—2021年西安市HIV感染者不同基因型CD4+T细胞计数分析
- Author:
Jing ZHANG
1
;
Cui-e YAO
1
;
Na XYU
1
;
Juanning WEI
1
Author Information
1. Department of Prevention and Health Care, the First Affiliated Hospital of the Air Force Military Medical University , Xi'an , Shanxi 710032 , China
- Publication Type:Journal Article
- Keywords:
Gene clusters;
Gene subtype;
HIV;
CD4+ T cells
- From:
Journal of Public Health and Preventive Medicine
2022;33(4):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the difference of CD4+ T cell count among different genotypes of HIV infected people in Xi'an from 2017 to 2021. Methods A total of 1 623 newly diagnosed AIDS patients in the AIDS prevention and control information system in Xi'an from 2017 to 2021 were selected. The genotypes of all the patients were sequenced, and the differences of CD4+T cell counts among different genotypes were analyzed. Results From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE（921/1623）、CRF07_ BC（145/1623）、CRF08_ BC (557/1623), the gene cluster is mainly CRF01_ AE (cluster 1) (185/ 1623) and CRF01_ AE (cluster 2) (1438/1623), where CRF01_ The average CD4+ T cell count of AE genotype was (146.26 ± 11.63)/μ L，CRF07_ The average CD4+ T cell count of BC genotype was (254.69 ± 15.49)/μ L，CRF08_ The average CD4+ T cell count of BC genotype was (217.96 ± 12.89)/μ L，CRF01_ The average number of CD4+ T cells in AE (cluster 1) was (185.58±12.79)/ μ L，CRF01_ The average number of CD4+ T cells in AE (cluster 2) was (179.90 ± 15.96)/ μ 50. There was significant difference in CD4+ T cell count among patients with different gene subtypes and gene clusters (P<0.05). Conclusion From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE, the gene cluster is mainly CRF01_ AE (Cluster 2), there were significant differences in CD4+T cell counts among patients with different gene subtypes and gene subsets, which could serve as a reference target for AIDS treatment in this Municipality.
