Clinicopathological characteristics and risk factors on hepatocellular carcinoma differentiation
10.3969/j.issn.1006-2483.2022.04.002
- VernacularTitle:不同分化程度肝细胞癌临床病理特征比较及危险因素分析
- Author:
Yang LIANG
1
,
2
;
Peiling WU
1
;
Yilin DENG
1
;
Yi-hua CHEN
2
;
Li MAO
1
;
Guangjie WANG
3
Author Information
1. Department of Public Health , Chengdu Medical College , Chendu , Sichuan 610500 , China
2. Pathology Department,The General Hospital of Western Theater Command PLA , Chendu , Sichuan 610083 , PR China
3. Cancer Diagnosis and Treatment Centre , The General Hospital of Western Theater Command PLA , Chendu , Sichuan 610083 , PR China
- Publication Type:Journal Article
- Keywords:
Ki67;
P53;
Hepatocellular carcinoma;
Clinicopathological characteristic
- From:
Journal of Public Health and Preventive Medicine
2022;33(4):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics and independent risk factors of hepatocellular carcinoma (HCC) differentiation. Methods A total of 108 HCC patients who underwent operation and treatment were reviewed and classified into low differentiation group (n= 29, 26.85%), medium differentiation group (n=53, 49.07%) and high differentiation group (n=26, 24.07%) according to pathological diagnosis. The clinicopathological characteristics and the expression levels of Ki67 and P53 in each group were compared and analyzed. Logistic regression model was used to analyze the risk factors for low differentiation of HCC. Results The proportion of cirrhosis, the positive rate of P53 and Ki67 expression level in different degrees of HCC differentiation were statistically significant (P<0.05). However, there were no significant differences in age, sex, tumor diameter, and hepatitis virus infection or tumor involvement of liver capsule between groups (P>0.05). Multivariate logistic analysis showed that cirrhosis (OR=3.408), high expression of Ki67 (OR=11.113) and positive P53 (OR=9.711) were the main risk factors for poorly differentiated HCC. Conclusion There are differences in clinical characteristics and expressions of Ki67 and P53 in HCC patients with different degrees of differentiation. Logistic regression analysis can identify clinicopathological risk factors affecting the degree of differentiation of HCC, which can provide criterion support for accurate diagnosis and prognostic treatment.