Hematological and histopathological changes of rat’s hearts experimentally infected with protoscoleces
https://doi.org/10.47665/tb.39.1.014
- Author:
Alsaadawi, M.A.
1
;
Al-Safar, A.H.
1
;
Al-Yasari, A.M.
1
;
Hussein, H.M.
1
;
Allawi, A.H.
1
;
Alsalih, N.J.
1
;
Kalef, D.A.
2
Author Information
1. College of Veterinary Medicine, Al-Muthanna University, Iraq
2. College of Veterinary Medicine, Baghdad University
- Publication Type:Journal Article
- Keywords:
Rats;
hydatid cysts;
heart sections;
immunity;
hematology.
- From:Tropical Biomedicine
2022;39(No.1):117-125
- CountryMalaysia
- Language:English
-
Abstract:
Hydatidosis; is a zoonotic disease caused by Echinococcus granulosus and characterized by
infiltration of inflammatory cells. This study was investigated the hematological and
histopathological changes in the hearts of rats injected with protoscoleces. Rats were injected
with protoscoleces collected from either liver of sheep, goats, and cows (from the abattoir of
Al-Muthanna province, south of Iraq) or isolated from infected humans from Al-Hussein
Teaching Hospital. Sheep protoscoleces showed a significant increase of lymphocytes that
refer to the induction of a high response of the immune system in rats. The numbers of WBC,
RBCs, and platelets were generally increased in rats injected with protoscoleces isolated
from sheep and goats. These changes could refer to the activation of defense mechanisms
against the hydatid injected materials. However, the levels of MCV, MCH, MCHC, MPV and
PDW were less than normal values. Heart sections of rats injected with protoscoleces isolated
from humans showed clear histological changes. While TSP, TGP and TCP exhibited variant
histopathological changes such as infiltration of inflammatory cells, pink glass appearance
and congestion of arteries. Thus, these alterations can be considered as additional evidence
of how the immune response reacts against the injected materials in the heart.
- Full text:8.2022my1321.pdf
