Antibody response of sheep to simultaneous vaccination of foot-and-mouth disease, peste des petits ruminants, sheep pox and goat pox, and bluetongue vaccines
https://doi.org/10.47665/tb.39.1.002
- Author:
Sareyyüpo lu, B.
1
;
Gülyaz, G.
2
;
Saraç, F.
3
;
Uzar, S.
3
;
Kabakl , Ö.
4
;
Çokçals¸ kan, C.
1
;
Gündüzalp, C.
1
;
Uzun, E.A.
1
;
Camli, O
5
Author Information
1. Republic of Turkey, Ministry of Agriculture and Forestry, Institute of Foot and Mouth Disease (SAP), Ankara, Turkey
2. Harran University, Faculty of Veterinary Medicine, Virology Department, Sanlurfa, Turkey
3. Republic of Turkey, Ministry of Agriculture and Forestry, Pendik Veterinary Control Institute, Viral Vaccine Production Laboratory, I. stanbul, Turkey
4. Republic of Turkey, Ministry of Agriculture and Forestry, Etlik Central Veterinary Research Institute, Viral Vaccine Production Laboratory, Ankara, Turkey
5. Middle East Technical University, Department of Statistics, Ankara, Turkey
- Publication Type:Journal Article
- Keywords:
Antibody response;
viruses;
simultaneous;
sheep;
vaccination
- From:Tropical Biomedicine
2022;39(No.1):47-54
- CountryMalaysia
- Language:English
-
Abstract:
There are many infectious animal diseases in Turkey and generally, vaccination is the primarly
control strategy to combat them. However, it is difficult to apply all vaccines in a definite
period in the field due to limitations of the labor and finance. Rapid vaccination and
effective use of labor can be possible with the help of simultaneous vaccine administrations.
The study aims to show the effects of simultaneous foot-and-mouth disease (FMD), peste
des petits ruminants (PPR), sheep pox and goat pox (SGP), and bluetongue (BT) vaccine
administration on the antibody response of sheep. For this aim, 30 sheep were divided into
one experiment and 5 control groups. Blood samples were collected in each group at 0, 30
and 60 days post-vaccination (DPV). Immune response was measured with virus neutralization
test (VNT) and, liquid phase blocking ELISA (LPBE) for FMDV; VNT for BTV and PPR. A live virus
challenge study was performed to determine the immune response of SGP vaccine. As a
result, antibody titers for each vaccine agent decreased on 60 DPV with the simultaneous
vaccination except FMD. The difference between means of antibody titer decrease with
single and simultaneous vaccinations is significant especially for BTV and PPR vaccines at
60DPV (p<0.05). Briefly, this decreasing immune response of three live vaccines can be
explained with the development of the interference, administration of these vaccines from
the same injection site, the effect of cytokines, especially IL-10 effect of SGP vaccine. It was
concluded that four vaccines can not be used simultaneously in sheep.
- Full text:8.2022my1311.pdf
