Potentiality of curcumin on ISHAK scoring system and the expressions of BAX, IL-17A, and EGF in the treatment of Schistosoma mansoni infection using Swiss albino mice
https://doi.org/10.47665/tb.39.1.001
- Author:
El Saftawy, E.A.
1
,
2
;
El-Dardiry, M.A.
3
;
Abd-Elaal, A.A.
4
,
5
;
Negm, M.S.I.
6
;
Amin, N.M.
1
,
7
Author Information
1. Medical Parasitology Department, Faculty of Medicine, Cairo University, Cairo, Egypt&
2. Medical Parasitology Department, Faculty of Medicine, Armed Forces College of Medicine, Cairo, Egypt
3. Medical Parasitology Department, Faculty of Medicine, Fayoum University, Cairo, Egypt
4. Medical Parasitology Department, Faculty of Medicine Kasr Al-Ainy, Cairo University, Giza, Egypt&
5. Postgraduate Department, Armed Forces College of Medicine (AFCM), Cairo, Egypt
6. Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Egypt
7. Masters degree of clinical pathology, Cairo University, Cairo, Egypt
- Publication Type:Journal Article
- Keywords:
BAX;
EGF;
IL-17A;
Curcumin;
ISHAK score.
- From:Tropical Biomedicine
2022;39(No.1):36-46
- CountryMalaysia
- Language:English
-
Abstract:
The present study evaluated the antiparasitic effect of curcumin extract on Schistosoma
mansoni in Swiss albino mice. The experimental design included four groups of S. mansoniinfected mice; without treatment (controls), curcumin-treated, Praziquantel (PZQ)-treated,
and PZQ +curcumin treated mice. The results showed that curcumin improved ISHAK confluent
necrosis score up to zero. PZQ +curcumin showed a significant reduction in portal
inflammation. Both activity and fibrosis demonstrated lower scores in all treated groups,
however, PZQ revealed a marked increase in confluent necrosis and interface hepatitis.
Besides, the lobular inflammation revealed worsening in the overall ISHAK score in all
treated groups compared with the control. Few periocular granulomas were recovered by
PZQ +curcumin treatment at day 35 post-treatment (6±1.2), P-value <0.05. Curcumin revealed a
mild reduction (60±7.376). Curcumin-treated groups, with and without PZQ, resulted in higher
significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control. However,
PZQ revealed a lower mean IRS value in BAX, higher IL-17A and EGF in the periovulatory
granuloma. It was concluded that PZQ +curcumin treatment had a potent synergistic outcome
through lessening the number of granulomas, the inflammatory events, and the expression
of EGF, and amelioration of apoptosis in the periovulatory granulomas if compared with
either PZQ or curcumin alone.
- Full text:8.2022my1310.pdf
