Advances in research of Musashi2 in solid tumors.
10.12122/j.issn.1673-4254.2022.03.20
- Author:
Ying Gui YANG
1
;
Min ZHAO
2
;
Teng Teng DING
1
;
Chu Ping NI
1
;
Qing You ZHENG
3
;
Xin LI
1
Author Information
1. Clinical Innovation and Research Center, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China.
2. Bonasia (Hefei) Medical Technology Co., Ltd., Hefei 230000, China.
3. Department of Urology Surgery, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China.
- Publication Type:Review
- Keywords:
Musashi2;
RNA-binding protein;
small molecular inhibitor;
solid tumor
- MeSH:
Animals;
Hedgehog Proteins;
Mammals/metabolism*;
Neoplasms/genetics*;
Neoplastic Stem Cells;
RNA-Binding Proteins/metabolism*;
Signal Transduction
- From:
Journal of Southern Medical University
2022;42(3):448-456
- CountryChina
- Language:Chinese
-
Abstract:
RNA binding protein (RBP) plays a key role in gene regulation and participate in RNA translation, modification, splicing, transport and other important biological processes. Studies have shown that abnormal expression of RBP is associated with a variety of diseases. The Musashi (Msi) family of mammals is an evolutionarily conserved and powerful RBP, whose members Msi1 and Msi2 play important roles in the regulation of stem cell activity and tumor development. The Msi family members regulate a variety of biological processes by binding and regulating mRNA translation, stability and downstream cell signaling pathways, and among them, Msi2 is closely related to embryonic growth and development, maintenance of tumor stem cells and development of hematological tumors. Accumulating evidence has shown that Msi2 also plays a crucial role in the development of solid tumors, mainly by affecting the proliferation, invasion, metastasis and drug resistance of tumors, involving Wnt/β-catenin, TGF-β/SMAD3, Akt/mTOR, JAK/STAT, Numb and their related signaling pathways (Notch, p53, and Hedgehog pathway). Preclinical studies of Msi2 gene as a therapeutic target for tumor have achieved preliminary results. This review summarizes the molecular structure, physiological function, role of Msi2 in the development and progression of various solid tumors and the signaling pathways involved.
