Clinical analysis of 10 cases with extramedullary plasmacytoma of the head and neck.
10.3760/cma.j.cn115330-20210424-00222
- Author:
Jun Fu WU
1
;
Li Yuan DAI
1
;
Meng CUI
1
;
Gang LI
1
;
Lu FENG
1
;
Rui Hua LUO
1
;
Wei DU
1
;
Shan Ting LIU
1
Author Information
1. Department of Head Neck and Thyroid Surgery, Henan Tumor Hospital, Zhengzhou 450008, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Female;
Head and Neck Neoplasms/therapy*;
Humans;
Male;
Middle Aged;
Multiple Myeloma/pathology*;
Plasmacytoma/surgery*;
Prognosis;
Retrospective Studies
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2022;57(2):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical characteristics, treatment methods and outcomes of extramedullary plasmacytoma of the head and neck. Methods: A retrospective analysis was conducted on 10 cases with extramedullary plasmacytoma of the head and neck who were admitted to Henan Tumor Hospital from January 2005 to January 2020. Among the 10 patients, 6 were male and 4 were female. The average age at diagnosis was 56.3 years old (34-74 years old). Among them, 3 cases were located in the nasal cavity, 2 cases in the nasopharynx, 1 case in the sinuses, 2 cases in the larynx, 1 case in the oropharynx, and 1 case in the cervical lymph nodes. Treatments were administered according to tumor size and resection extent. Complete surgical excision (negative margins) was preferred, followed by adjuvant radiotherapy or radiotherapy alone. The clinical characteristics, diagnosis, treatment and prognosis of EMP were analyzed. Results: The patients' symptoms were not specific, frequently with local obstruction symptom and localized masses. All patients were confirmed pathologically as suffering from monoclonal plasmacytoma, with negative bone marrow biopsy and negative skeletal survey. Five patients received surgery, 3 received radiotherapy, and 2 received surgery with additional radiation. The follow-up time was 16-125 months, with a median of 92 months. Two patients developed into multiple myeloma. One patient who received radiotherapy after surgery relapsed after 7 years of follow-up and again received surgical treatment, with no evidence of second recurrence. The remaining patients had no recurrence or progression. Conclusion: Extramedullary plasmacytoma of the head and neck has a good prognosis. Surgical treatment can be considered for completely resectable lesions.
