Incidence and risk factors of ischemic stroke in patients with type 2 diabetes among urban workers in Beijing, China.
- Author:
Jun Hui WU
1
;
Yi Qun WU
1
;
Yao WU
1
;
Zi Jing WANG
1
;
Tao WU
1
;
Xue Ying QIN
1
;
Meng Ying WANG
1
;
Xiao Wen WANG
1
;
Jia Ting WANG
1
;
Yong Hua HU
1
Author Information
1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Diabetes complication;
Diabetes mellitus, type 2;
Incidence;
Stroke
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Beijing/epidemiology*;
Diabetes Mellitus, Type 2/epidemiology*;
Female;
Humans;
Incidence;
Ischemic Stroke;
Male;
Middle Aged;
Prospective Studies;
Risk Factors;
Stroke/etiology*
- From:
Journal of Peking University(Health Sciences)
2022;54(2):249-254
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the incidence of ischemic stroke after the onset of type 2 diabetes, and further analyze the risk factors, so as to provide a basis for further research.
METHODS:The data were obtained from the database of the Beijing Urban Employee Basic Medical Insurance Database. The study used a prospective design to describe the incidence of ischemic stroke in patients with type 2 diabetes. In our study, these patients were followed up for seven years. Multivariate Logistic regression models were used to analyze the risk factors of ischemic stroke in patients with type 2 diabetes.
RESULTS:A total of 185 813 newly diagnosed type 2 diabetes patients were enrolled, with an average age of (58.5±13.2) years, and 49.0% of them were males. A total of 10 393 patients with newly diagnosed ischemic stroke occurred in 7 years, with a cumulative incidence of 5.6% and an incidence density of 8.1/1 000 person-years. Ischemic stroke occurred in all age groups in patients with type 2 diabetes. The cumulative incidence was 1.5% (95%CI: 1.3%-1.6%) in group ≤44 years old, 3.6% (95%CI: 3.4%-3.7%) in group 45-54 years old, 5.4% (95%CI: 5.2%-5.5%) in group 55-64 years old, and 9.2% (95%CI: 9.0%-9.4%) in group ≥65 years old, and the cumulative incidence increased with age (P < 0.05). Cumulative incidence rate of the males (6.8%, 95%CI: 6.7%-7.0%) was higher than the females (4.4%, 95%CI: 4.3%-4.6%). Among the patients < 80 years old, the cumulative incidence rate of the males was higher than that of the females in all the age groups. In the patients ≥80 years of age, the cumulative incidence was higher in the females (9.2%) than in the males (7.9%). Further analysis revealed that complications, such as coronary heart disease (OR=3.18, 95%CI: 2.72-3.72), heart failure (OR=1.53, 95%CI: 1.32-1.79) and kidney failure (OR=1.45, 95%CI: 1.20-1.75) were associated with ischemic stroke in the patients with type 2 diabetes.
CONCLUSION:The incidence level of ischemic stroke in patients with type 2 diabetes is high. It is necessary to strengthen the management of risk factors in elderly patients, screen the complications of type 2 diabetes as early as possible, and take active preventive and control measures.
