Neoadjuvant immunotherapy in microsatellite stability or mismatch repair proficient colorectal cancer.
10.3760/cma.j.cn441530-20211217-00505
- VernacularTitle:微卫星稳定或错配修复正常结直肠癌的新辅助免疫治疗
- Author:
Jian Wei ZHANG
1
;
Yan Hong DENG
1
Author Information
1. Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
- Publication Type:Journal Article
- Keywords:
Combination treatment;
Immunotherapy;
Microsatellite stability;
Mismatch repair proficient;
Neoadjuvant treatment
- MeSH:
Colorectal Neoplasms/therapy*;
DNA Mismatch Repair/genetics*;
Humans;
Immunotherapy;
Microsatellite Repeats;
Neoadjuvant Therapy
- From:
Chinese Journal of Gastrointestinal Surgery
2022;25(3):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy has become an important treatment option for microsatellite instability-high (MSI-H) and mismatch repair deficient (dMMR) colorectal cancer. From late-line to first-line treatment, and even in neoadjuvant setting for early stage colorectal cancer, promising efficacy was observed with immunotherapy. In microsatellite stability (MSS) or mismatch repair proficient (pMMR) colorectal cancer, the researches of neoadjuvant immunotherapy have been conducted constantly. This paper focuses on the recent researches and progress of neoadjuvant immunotherapy for MSS or pMMR colorectal cancer. Neoadjuvant immunotherapy alone led to a good pathological response in a subset of patients. Studies of induction or consolidation immunotherapy before or after neoadjuvant chemoradiotherapy or concurrent immunotherapy during radiotherapy showed higher pathological complete remission (pCR) rates as compared to standard chemoradiotherapy. Studies on sequential dual immunotherapy after radiochemotherapy and targeted therapy combined with neoadjuvant immunotherapy are ongoing. At present, most of these are pilot studies with small sample size. More researches and long-term follow-up are needed to prove the efficacy of neoadjuvant immunotherapy in MSS or pMMR colorectal cancer.
