Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing.
10.3760/cma.j.cn501120-20210218-00057
- Author:
Yi Xi WANG
1
;
Jun Jie CHEN
1
;
Ying CEN
1
;
Zheng Yong LI
1
;
Zhen Yu ZHANG
1
Author Information
1. Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Review
- MeSH:
Diabetes Mellitus;
Exosomes;
Humans;
Mesenchymal Stem Cells;
Stem Cells;
Wound Healing
- From:
Chinese Journal of Burns
2022;38(5):491-495
- CountryChina
- Language:Chinese
-
Abstract:
Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism, and refractory diabetic wounds bring heavy burdens to patients and society. Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages and are gradually playing important roles in wound healing. In recent years, researches have shown that exosomes derived from adipose-derived mesenchymal stem cells (ADSC-EXOs) can promote the healing of diabetic wounds by participating in various processes of wound healing. This article reviews the pathological mechanism leading to impaired healing of diabetic wounds, the related mechanism and the application prospect of ADSC-EXOs in promoting diabetic wound healing.
