Research advances on mesenchymal stem cell-derived extracellular vesicles in promoting angiogenesis of diabetic ulcers.
10.3760/cma.j.cn501120-20201207-00520
- Author:
Wen Jian LIU
1
;
De Wu LIU
2
Author Information
1. Department of Burns and Plastic Surgery, Jiangxi General Hospital of Armed Police, Nanchang 330030,China.
2. Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
- Publication Type:Review
- MeSH:
Diabetes Complications;
Diabetes Mellitus;
Extracellular Vesicles;
Humans;
Mesenchymal Stem Cells;
Neovascularization, Pathologic;
Ulcer;
Wound Healing/physiology*
- From:
Chinese Journal of Burns
2022;38(4):393-399
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles are nanoparticles secreted by most eukaryotic cells and play important roles in material transport and information transmission between cells, involved in inflammation, angiogenesis, antigen presentation, cell apoptosis, cell differentiation, and other biological processes. The culture supernatant of mesenchymal stem cells is rich in extracellular vesicles, and the extracellular vesicles can regulate the formation of new blood vessels, a key step in wound healing and tissue repair. The persistence of diabetic ulcers is closely related to the blocked formation of wound vascular network. This article reviews the role of extracellular vesicles derived from mesenchymal stem cells in promoting angiogenesis of diabetic ulcers, in order to provide a new idea for the treatment of diabetic ulcers.
