Research advances on the influence of poor dietary habits on the development of keloids.
10.3760/cma.j.cn501120-20210401-00112
- Author:
Qi XU
1
;
Wei LIU
2
Author Information
1. Institute of Plastic Surgery, Weifang Medical University, Weifang 261042, China.
2. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
- Publication Type:Review
- MeSH:
Diet/adverse effects*;
Feeding Behavior;
Humans;
Inflammation/metabolism*;
Keloid/physiopathology*;
NF-kappa B/metabolism*;
Tumor Necrosis Factor-alpha/metabolism*
- From:
Chinese Journal of Burns
2022;38(4):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Long-term poor dietary habits can cause changes in the intestinal flora, resulting in the production of a large number of lipopolysaccharide, increase intestinal mucosal permeability, and activate the entrance of a large number of inflammatory factors into the portal vein. In addition, a high carbohydrate diet can increase liver metabolic burden, increase mitochondrial oxidative phosphorylation, leading to oxidative stress, generate new fat during adenosine triphosphate synthesis, and thus resulting in ectopic fat accumulation, which further activate nuclear factor-κB signaling pathway and release inflam- matory factors such as tumor necrosis factor-α, interleukin-1β (IL-1β), IL-6, and so on. This leads to obesity and insulin resis- tance, ultimately triggering systemic low-grade inflammation. This article reviews the mechanism of poor dietary habits leading to systemic low-grade inflammation, the clinical and experimental research progress of keloids and systemic low-grade inflammation, the association between dietary habits and keloid constitution, and puts forward the hypothesis that poor dietary habits may lead to the occurrence and development of keloids.
