Research advances on thymosin β4 in promoting wound healing.
10.3760/cma.j.cn501120-20210221-00059
- VernacularTitle:胸腺素β4促进创面愈合的研究进展
- Author:
Yi Xuan GAO
1
;
Ling Feng WANG
1
;
Te BA
1
;
Sheng Jun CAO
1
;
Jun Liang LI
2
;
Fang LI
2
;
Biao ZHOU
1
Author Information
1. Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China.
2. Burn Medical Institute of Inner Mongolia Autonomous Region, Baotou 014010, China.
- Publication Type:Review
- MeSH:
Burns/drug therapy*;
Humans;
Pressure Ulcer;
Thymosin/therapeutic use*;
Wound Healing/physiology*
- From:
Chinese Journal of Burns
2022;38(4):378-384
- CountryChina
- Language:Chinese
-
Abstract:
With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin β4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin β4 has biological activities of promoting angiogenesis, anti-inflammation, anti-apoptosis, and anti-fibrosis, and has many important functions in wound repair. Thymosin β4 has been observed to promote the healing of various wounds, such as burns, diabetic ulcers, pressure ulcers. This paper will review the molecular structure, mechanism of wound healing promotion, pharmacokinetics, and clinical application of thymosin β4, aiming to introduce its potential in wound treatment and the shortcomings of current researches.
