Treatment of chronic refractory wound with autologous platelet-rich plasma in a hemophilia A patient after knee joint surgery.
10.3760/cma.j.cn501120-20210202-00045
- Author:
Ri Xing ZHOU
1
;
Yong Sheng DONG
1
;
Wang Biao ZHOU
1
Author Information
1. Department of Burns and Plastic Surgery, Maoming People's Hospital, Maoming 525099, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Hemophilia A/therapy*;
Humans;
Knee Joint/surgery*;
Male;
Platelet-Rich Plasma;
Skin Transplantation;
Soft Tissue Injuries/surgery*;
Treatment Outcome;
Wound Healing
- From:
Chinese Journal of Burns
2022;38(4):369-372
- CountryChina
- Language:Chinese
-
Abstract:
On December 22, 2017, a 35-year-old male hemophilia A patient with a secondary chronic refractory wound after left knee joint surgery was transferred from the Department of Hematology of Maoming People's Hospital to the Department of Burns and Plastic Surgery in the same hospital. The physical examination revealed that the patient's left knee joint was swollen, with a full-thickness skin defect wound of 4 cm×4 cm on the lateral side of the joint and a large number of dark red blood clots at the bottom of the wound. The wound bleeding was controlled by intravenous infusion of plasma, cryoprecipitate, and human coagulation factor Ⅷ. After con- ventional debridement and dressing changes until the wound infection was controlled and necrotic tissue was removed, a subcutaneous cavity wound of 2 cm×2 cm in area and 3 cm in depth remained in the left knee joint and was difficult to heal. Nineteen days after transfer, the patient received autologous platelet-rich plasma (PRP) treatment, and 32 days after PRP treatment, the wound in left knee joint was healed with epithelialization. This case suggests that autologous PRP therapy would be a good option for hemophilia complicated chronic refractory wounds when they could not be repaired by surgery.
