Research advances on stem cell therapy for diabetic foot wounds.
10.3760/cma.j.cn501120-20210828-00292
- Author:
Zhi Hu LIN
1
;
Jun WANG
1
;
Zun Hong LIANG
1
;
Yun Chuan PAN
1
Author Information
1. Department of Burn and Skin Repair, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China.
- Publication Type:Review
- MeSH:
Cell Differentiation;
Diabetes Mellitus;
Diabetic Foot/therapy*;
Humans;
Stem Cell Transplantation;
Wound Healing/physiology*
- From:
Chinese Journal of Burns
2022;38(3):281-286
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic foot wound repair is a challenging issue in clinical practice. Due to the influence of multiple factors including the damage and regeneration failure of local tissue, the impaired pathways of wound repairing through blood vessels and nerve nutrition, and disorders of a variety of cellular factors, traditional treatment methods are often difficult to achieve good therapeutic effects. Stem cells are a type of cells with potentials of multidirectional differentiation, which also possess functions such as regulating immunity and paracrine to facilitate the comprehensive wound repair, so they have promising application prospect at present for the treatment of diabetic foot wounds. Because the relevant parameters of stem cell treatment are in the exploratory phase, there were no standardized data. This paper reviews the application of stem cells in the research of diabetic foot wound treatment over the past 6 years, analyzing and summarizing the contents in focused aspects including the types and sources of stem cells, effects of donor age and gender on stem cells, mode of administration, transplantation survival rate and safety, which may provide a reference for further application of stem cells in the clinical treatment of diabetic foot wound.
