Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro.
10.3760/cma.j.cn501120-20201020-00442
- Author:
Dong Hao LANG
1
;
Te BA
2
;
Sheng Jun CAO
2
;
Fang LI
2
;
Hang DONG
2
;
Jun Liang LI
2
;
Ling Feng WANG
2
Author Information
1. The Third Clinical Medical College of Inner Mongolia Medical University, Hohhot 010110, China.
2. Department of Burns, the Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China.
- Publication Type:Review
- MeSH:
Adenoids/metabolism*;
Hedgehog Proteins/metabolism*;
Humans;
Quality of Life;
Signal Transduction;
Sweat/metabolism*;
Sweat Glands/physiology*
- From:
Chinese Journal of Burns
2022;38(2):195-200
- CountryChina
- Language:Chinese
-
Abstract:
The damage of sweat glands in patients with extensive deep burns results in the loss of thermoregulation, which seriously affects the quality of life of patients. At present, there are many researches on the repair of sweat gland function, but the mechanism of human sweat gland development has not been fully clarified. More and more studies have shown that the cascaded pathways of Wnt/β-catenin, ecto- dysplasin A/ectodysplasin A receptor/nuclear factor-κB, sonic hedgehog, and forkhead box transcription factor jointly affect the development of sweat glands, and it has been reported that the cascaded signaling pathways can be used to achieve the reconstruction of sweat adenoid cells in vitro. This article reviews the signaling pathways that affect the development of sweat glands and their involvement in the reconstruction of sweat adenoid cells in vitro.
