Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization.
10.3760/cma.j.cn501120-20211210-00411
- VernacularTitle:皮肤
γδT细胞各亚群在创面再上皮化过程中的调控作用及其相关机制
- Author:
Wei Feng HE
1
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Wound Repair and Regeneration, Chongqing 400038, China.
- Publication Type:Journal Article
- MeSH:
Prospective Studies;
Re-Epithelialization;
Skin;
T-Lymphocyte Subsets;
T-Lymphocytes
- From:
Chinese Journal of Burns
2022;38(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Re-epithelialization is one of the core links that determines the healing process of skin wounds. The proliferation and differentiation of epidermal stem cells to form new epidermal tissue is the histological basis of re-epithelialization, and the smooth progress of the cell differentiation process of epidermal stem cells-precursor cells-terminal cells is the cytological basis for the continuous formation of new epidermal tissue. The proliferation of stem cells and their differentiation into precursor cells are the determinants of the proliferative potential of newly formed epidermal tissue, while the expansion and differentiation of precursor cells into terminal cells are key factors determining the rate of new epidermal tissue formation. The tissue microenvironment plays a key regulatory role in the process of wound re-epithelialization, and cell growth factor and inflammatory mediators are the two main components of tissue microenvironment, which play regulatory role in different aspects of proliferation and differentiation of epidermal stem cells, jointly promoting the smooth progress of wound re-epithelialization As an important part of skin immune system, the subsets of gamma-delta (γδ) T cells play crucial role in dynamically shaping early wound microenvironment via secreting different cell growth factors and inflammatory factors. From the prospective of immune microenvironment of wound, this paper discusses the role of skin γδ T cells in maintaining the balance of stem cell proliferation and differentiation and regulating wound re-epithelialization, providing a new direction for the prevention and treatment of refractory wound.
