Advances in gut microbiomes and immunology of IgG4-related hepatobiliary and pancreatic diseases.
10.3760/cma.j.cn501113-20210907-00458
- Author:
Xia Xia PAN
1
;
Zhong Wen WU
1
Author Information
1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China.
- Publication Type:Review
- MeSH:
Autoimmune Diseases/diagnosis*;
Gastrointestinal Microbiome;
Humans;
Immunoglobulin G;
Immunoglobulin G4-Related Disease/pathology*;
Pancreatic Diseases
- From:
Chinese Journal of Hepatology
2022;30(4):452-456
- CountryChina
- Language:Chinese
-
Abstract:
IgG4-related disease (IgG4-RD) is an immune-mediated condition associated with chronic fibroinflammatory lesions that can affect nearly any organ. IgG4-related hepatobiliary and pancreatic diseases are IgG4-RD involving the hepatobiliary and pancreatic system, which is characterized with elevated serum IgG4 concentrations, large numbers of IgG4 positive lymphoplasma cells infiltration in affected organs, storiform fibrosis, and imaging changes of organ morphology. Due to the lack of reliable biomarkers, histopathology is still an important basis for diagnosis. The pathogenesis of IgG4-related hepatobiliary and pancreatic diseases has not been clarified. This review focuses on the recent advances in intestinal microecology-immunology, host genetics-immunity and recurrence monitoring of IgG4-related hepatobiliary and pancreatic diseases.
