Research Progress on the Role of Mitochondrial DNA in the Pathogenesis of Chronic Liver Disease.
10.3760/cma.j.cn501113-20210622-00296
- VernacularTitle:线粒体DNA在慢性肝病发病机制中作用的研究进展
- Author:
Xing ZHANG
1
;
Yang Yang HU
1
;
Yue LUO
1
;
Ya Dong WANG
1
;
Cai Yan ZHAO
1
Author Information
1. Department of Infectious Diseases, the Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050051, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Autophagy;
DNA, Mitochondrial/metabolism*;
Humans;
Liver Diseases;
Mitochondria;
Oxidative Stress;
Reactive Oxygen Species/metabolism*
- From:
Chinese Journal of Hepatology
2022;30(4):447-451
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial DNA is the mitochondria's own genetic material located within the mitochondrial matrix and is involved in cellular metabolism and energy supply. Mitochondrial DNA damage exacerbates oxidative stress by increasing the release of reactive oxygen species, while mitochondrial DNA release also triggers apoptosis and activates immune inflammatory responses through damage-related molecular patterns. Mitochondrial autophagy regulates mitochondrial DNA damage and release through a negative feedback mechanism to maintain intracellular homeostasis. Recent studies have shown that the occurrence and development of chronic liver disease are closely related to mitochondrial DNA-mediated immune inflammatory responses and oxidative stress.
