Clinical research in cell therapy of liver diseases: progress and challenges.
10.3760/cma.j.cn501113-20220222-00083
- VernacularTitle:细胞治疗肝病临床研究：进展与挑战
- Author:
Lei SHI
1
;
Ze Rui WANG
2
;
Tian Tian LI
3
;
En Qiang LINGHU
2
;
Fu Sheng WANG
1
Author Information
1. Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, 100039 Beijing, China.
2. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China,230001 Hefei, China.
3. Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, 100039 Beijing, China Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital,100853 Beijing, China.
- Publication Type:Review
- MeSH:
Cell- and Tissue-Based Therapy;
Humans;
Liver Diseases/therapy*;
Liver Transplantation/methods*;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells
- From:
Chinese Journal of Hepatology
2022;30(3):237-243
- CountryChina
- Language:Chinese
-
Abstract:
The high incidence of chronic liver disease is a serious threat to public health, and the current comprehensive internal medicine treatment is ineffective. Liver transplantation is limited by the shortage of liver source and post-transplant rejection, and thus unmet the clinical needs. More importantly, cell therapy shows great promise for the treatment of chronic liver disease. Over recent years, domestic and foreign scholars have carried out a variety of cell therapy preclinical and clinical trials for critical liver disease, and achieved certain results, providing new methods for the treatment of chronic liver diseases. This review discusses the cell therapy research status and application progress, various existing problems and challenges, and key issues of mesenchymal stem cells in the treatment of chronic liver diseases.
