Acute-on-chronic liver failure: definition, diagnosis, and pathogenesis.
10.3760/cma.j.cn501113-20211027-00522
- VernacularTitle:慢加急性肝衰竭：定义、诊断与发病机制
- Author:
Jia Qi LI
1
;
Jun LI
1
Author Information
1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- Keywords:
Acute-on-chronic liver failure;
Diagnosis;
Hepatitis B;
Pathogenesis;
Prognosis
- MeSH:
Acute-On-Chronic Liver Failure/therapy*;
Humans;
Prognosis
- From:
Chinese Journal of Hepatology
2022;30(2):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is a form of complex syndrome with acute deterioration of liver function that occurs on the basis of chronic liver disease, and is accompanied by hepatic and extrahepatic organ failure with high mortality rate. The short-term mortality rate of comprehensive internal medicine treatment is as high as 50%-90%. This paper summarizes the current common definitions and diagnostic criteria, early-warning prediction models, and pathogenesis of ACLF.
