Management of hepatolenticular degeneration during pregnancy.
10.3760/cma.j.cn501113-20200807-00441
- Author:
Jie BAI
1
;
Su Jun ZHENG
1
;
Zhong Ping DUAN
1
Author Information
1. Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing You An Hospital, Capital Medical University & Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Management;
Pregnancy;
Wilson disease
- MeSH:
Copper;
Copper-Transporting ATPases/genetics*;
Female;
Hepatolenticular Degeneration/therapy*;
Humans;
Mutation;
Pregnancy
- From:
Chinese Journal of Hepatology
2022;30(1):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Hepatolenticular degeneration (Wilson's disease, WD) is a kind of autosomal recessive genetic disease characterized by disorders of copper metabolism. It is caused by mutations in the ATP7B gene, resulting in impaired excretion of copper into the bile, and then pathological deposition in the liver, brain, and other organs. Early diagnosis and treatment can significantly improve the prognosis of patients with WD. However, there is still no clear consensus on the treatment and management of WD during pregnancy. Herein, the clinical management of WD during pregnancy is summarized for clinicians' reference.
