Study on the diagnostic value of transient elastography, APRI and FIB-4 for liver fibrosis in children with non-alcoholic fatty liver disease.
10.3760/cma.j.cn501113-20210105-00007
- Author:
Shu Li HE
1
;
Shuang Jie LI
1
;
Min LIU
1
;
Wen Xian OUYANG
1
;
Wei Jian CHEN
1
;
Xi ZHENG
1
;
Tao JIANG
1
;
Yan Fang TAN
1
;
Zhen KANG
1
;
Xiao Mei QIN
1
;
Ying YU
1
Author Information
1. Liver Disease Center of Hunan Children's Hospital, Changsha 410000, China.
- Publication Type:Journal Article
- Keywords:
Aspartate aminotransferase to platelet ratio index;
Diagnosis;
Elastography;
Fibrosis index based on four factors;
Hepatic fibrosis;
Non-alcoholic fatty liver disease
- MeSH:
Aspartate Aminotransferases;
Biomarkers;
Child;
Elasticity Imaging Techniques;
Humans;
Liver/pathology*;
Liver Cirrhosis/pathology*;
Liver Function Tests;
Non-alcoholic Fatty Liver Disease/pathology*;
ROC Curve;
Retrospective Studies
- From:
Chinese Journal of Hepatology
2022;30(1):81-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the diagnostic value of transient elastography, aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis index based on 4 factors (FIB-4) for liver fibrosis in children with non-alcoholic fatty liver disease (NAFLD). Methods: A retrospective study was conducted on 100 cases of nonalcoholic fatty liver disease in Hunan Children's Hospital between August 2015 to October 2020 to collect liver tissue pathological and clinical data. The receiver operating characteristic curve (ROC curve) was used to analyze the diagnostic value of liver stiffness measurement (LSM), APRI and FIB-4 in the diagnosis of different stages of liver fibrosis caused by NAFLD in children. Results: The area under the ROC curve (AUC) value of LSM, APRI and FIB-4 for diagnosing liver fibrosis (S≥1) were 0.701 [95% confidence interval (CI): 0.579 ~ 0.822, P = 0.011], 0.606 (95%CI: 0.436 ~ 0.775, P = 0.182), and 0.568 (95%CI: 0.397 ~ 0.740, P = 0.387), respectively. The best cut-off values were 6.65 kPa, 21.20, and 0.18, respectively. The AUCs value of LSM, APRI, and FIB-4 for diagnosing significant liver fibrosis (S≥ 2) were 0.660 (95% CI: 0.552 ~ 0.768, P = 0.006), 0.578 (95% CI: 0.464 ~ 0.691, P = 0.182) and 0.541 (95% CI: 0.427 ~ 0.655, P = 0.482), respectively. The best cut-off values were 7.35kpa, 24.78 and 0.22, respectively. The AUCs value of LSM, APRI and FIB-4 for the diagnosis of advanced liver fibrosis (S≥ 3) were 0.639 (95% CI: 0.446 ~ 0.832, P = 0.134), 0.613 (95% CI: 0.447 ~ 0.779, P = 0.223) and 0.587 (95% CI: 0.411 ~ 0.764, P = 0.346), respectively. The best cut-off values were 8.55kpa, 26.66 and 0.27, respectively. Conclusion: The transient elastography technique has a better diagnostic value than APRI and FIB-4 for liver fibrosis in children with NAFLD.
