Clinical application of serum Golgi protein 73 in patients with chronic liver diseases.
10.3760/cma.j.cn501113-20210210-00084
- Author:
Yan Na LIU
1
;
Ming Jie YAO
2
;
Su Jun ZHENG
3
;
Xiang Mei CHEN
1
;
Xiang Yi LIU
4
;
Peng HU
5
;
Qi Shui OU
6
;
Xiao Guang DOU
7
;
Hong Song CHEN
8
;
Zhong Ping DUAN
3
;
Jin Lin HOU
9
;
Yue Min NAN
10
;
Zhi Liang GAO
11
;
Xiao Yuan XU
12
;
Hui ZHUANG
1
;
Feng Min LU
13
Author Information
1. Department of Microbiology and Center of Infectious Diseases, Peking University Health Science Center, Beijing 100191, China.
2. Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
3. Liver Diseases Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
4. Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
5. Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
6. Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
7. Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang 110022, China.
8. Hepatology Institute, Peking University People's Hospital, Beijing 100044, China.
9. Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
10. Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
11. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
12. Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
13. Department of Microbiology and Center of Infectious Diseases, Peking University Health Science Center, Beijing 100191, China Hepatology Institute, Peking University People's Hospital, Beijing 100044, China.
- Publication Type:Journal Article
- Keywords:
Golgi protein;
Liver cirrhosis;
Liver diseases;
Liver fibrosis;
Liver inflammation;
Serum biomarker
- MeSH:
Biomarkers;
Carcinoma, Hepatocellular;
Golgi Apparatus;
Humans;
Liver Cirrhosis;
Liver Neoplasms
- From:
Chinese Journal of Hepatology
2022;30(1):4-8
- CountryChina
- Language:Chinese
-
Abstract:
Golgi protein 73 (GP73) is a transmembrane protein on the Golgi apparatus and can be cut and released into the blood. In recent years, an increasing number of clinical studies have shown that the elevated serum GP73 level is closely related to liver diseases. And thus GP73 is expected to be used as a new serum marker for assessing progress of chronic liver diseases. Herein, the clinical application of serum GP73 in chronic hepatitis, liver fibrosis, liver cirrhosis and hepatocellular carcinoma with different etiologies was reviewed based on available literatures; and a research outlook in this field is made.
