Research progress in association of neurological disorders and periodontal diseases.
10.3760/cma.j.cn112144-20220312-00103
- Author:
Xue Bing BAI
1
;
Lu Jun ZHOU
1
;
Wen Zhen LIN
1
;
Ya Qin ZHU
1
Author Information
1. Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
Depressive Disorder, Major/complications*;
Humans;
Inflammation/complications*;
Periodontal Diseases/complications*;
Periodontium
- From:
Chinese Journal of Stomatology
2022;57(5):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases and neurological disorders. This article presents epidemiological and biological evidences that periodontal diseases can induce or exacerbate neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis and major depressive disorder, and analyzes the possible mechanisms. The importance of maintaining oral health as well as preventing and treating periodontal diseases are emphasized. At the same time, this may provide novel approaches to study the relationship between periodontal diseases and neurological disorders in the prevention and treatment strategies of neurological disorders.
