Can periodontitis affect colorectal cancer by altering microbiota balance?
10.3760/cma.j.cn112144-20220303-00090
- Author:
Ting AN
1
;
Zuo Min WANG
1
Author Information
1. Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
- Publication Type:Review
- MeSH:
Colorectal Neoplasms;
Dysbiosis/complications*;
Gastrointestinal Microbiome;
Humans;
Microbiota;
Periodontitis/complications*;
Tumor Microenvironment
- From:
Chinese Journal of Stomatology
2022;57(5):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Emerging evidence suggests that, along with dietary, genetic and environmental factors, gut microbiota plays a role in the progress of colorectal cancer. Dysbiosis of oral flora in patients with periodontitis affects the composition of microbial community in the gut, impairs gut barrier function, and induces a proinflammatory microenvironment, all of which contribute to the progression of colorectal cancer. In view of the influences by microbiota dysbiosis, this article reviews the role of periodontitis in affecting the occurrence and development of colorectal cancer.
