Intra-articular Morphine for Pain Relief after Arthroscopic Knee Surgery.
10.4097/kjae.1998.35.1.120
- Author:
Sun Joon BAI
1
;
Bum Joon CHO
;
Soon Ho NAM
;
Haeng Chul LEE
;
Eun Kyoung AHN
Author Information
1. Department of Anesthesiology, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Analgesia: postoperative;
Analgesic technique: intraarticular;
Analgesics: morphine;
Surgery: arthroscopy;
knee
- MeSH:
Analgesics;
Analgesics, Opioid;
Humans;
Knee*;
Morphine*;
Postoperative Period;
Receptors, Opioid
- From:Korean Journal of Anesthesiology
1998;35(1):120-124
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. However, reports on pain relief with intra-articular morphine after arthroscopic knee operations are conflicting. In this study we examined the analgesic effects of the intraarticular administration of morphine after knee surgery. METHODS: In a double-blind, randomized trial, we studied 26 patients who had received one of two injections at the end of surgery. The patients in group M(n=11) received 3 mg of morphine intraarticularly; those in group P(n=15), saline 20 ml intraarticularly as a placebo. RESULTS: Patients in the morphine group had significantly lower pain scores throughout the 24-h postoperative period compared with those in the placebo group(P<0.05). There was less requirement for supplementary analgesics in the morphine group. CONCLUSIONS: Low doses of intraarticular morphine can significantly reduce pain after knee surgery without any systemic side effect.
