Research progress on the regulatory mechanism of non-coding RNA in arsenic toxicity.
10.3760/cma.j.cn121094-20210222-00095
- Author:
Ning BU
1
;
Hai Yan SONG
1
;
Su Hua WANG
1
Author Information
1. College of Public Health, Baotou Medical College, Baotou 014000, China.
- Publication Type:Journal Article
- Keywords:
Arsenic;
Arsenic poisoning;
CircRNAs;
Long non-coding RNAs;
MicroRNAs
- MeSH:
Arsenic/toxicity*;
Arsenic Poisoning;
Humans;
MicroRNAs/genetics*;
RNA, Circular;
RNA, Long Noncoding/genetics*
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is a non-metallic element, and the International Agency for Research on Cancer has identified arsenic and its compounds as carcinogens. Arsenic and its compounds can be absorbed through the respiratory tract, skin and digestive tract, distributed in the liver, kidney, lung and skin, and cause damage. Non-coding RNAs are closely related to arsenic-induced nervous system disorders, cell necrosis, reproductive toxicity, and carcinogenesis. In recent years, the network regulation of microRNAs (miRNAs) , long non-coding RNAs (lncRNAs) , and circular RNAs (circRNAs) among non-coding RNAs in various diseases induced by arsenic has become a new research field. This paper summarizes the existing scientific research results, and expounds the mechanism of miRNAs, lncRNAs and circRNAs in arsenic toxicity, and provides basic data and theoretical basis for the prevention and treatment of arsenic poisoning.
