Research progress of C-X-C motif chemokine ligand 12 and its receptor signaling axis in the regulation of pulmonary fibrosis.
10.3760/cma.j.cn121094-20210413-00196
- VernacularTitle:CXC趋化因子配体12及其受体信号轴调控肺纤维化的研究进展
- Author:
Qi Xian SUN
1
,
2
;
Min MU
1
,
2
;
Xin Rong TAO
1
,
2
Author Information
1. School of Medicine, Anhui University of Science and Technology, Huainan 232001, China
2. Key Laboratory of Industrial Dust Prevention and Control & Occupational Health and Safety, Ministry of Education, Anhui University of Science and Technology, Huainan 232001, China.
- Publication Type:Review
- Keywords:
C-X-C motif chemokine ligand 12 (CXCL12);
Inhibitor;
Pulmonary fibrosis;
Receptor
- MeSH:
Chemokine CXCL12;
Endothelial Cells/pathology*;
Humans;
Ligands;
Lung/pathology*;
Pulmonary Fibrosis/pathology*;
Receptors, CXCR4
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(3):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is an irreversible interstitial lung disease characterized by lung parenchyma remodeling and collagen deposition. In recent years, the incidence and mortality of pulmonary fibrosis caused by unknown causes have risen. However, its pathogenesis is still unclear. C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor 4 (CXCR4)/CXCR7 signal axis plays a critical regulatory role in pulmonary fibrosis disease. In addition, the signal axis has been shown to regulate recruitment and migration of circulating fibrocytes, mesenchymal stem cells to the damage lung tissue, the migration of endothelial cells, the proliferation and differentiation of fibroblasts and endothelial cells, which further affects the occurrence and progression of pulmonary fibrosis. In this review, we summarized the pathogenesis and treatment research progress of CXCL12 and its receptor CXCR4/CXCR7 in the occurrence and progression of pulmonary fibrosis.
